Google makes so much money that it’s now worth three times more than every U.S. airline combined.

Great tech opportunities happen only once.

Everybody has a product to sell—no matter whether you’re an employee, a founder, or an investor. It’s true even if your company consists of just you and your computer. Look around. If you don’t see any salespeople, you’re the salesperson.

My own answer to the contrarian question is that most people think the future of the world will be defined by globalization, but the truth is that technology matters more.

The college kids should think hard about what they're doing. If you have a great idea for a company, there's no right time to start it, and it's often better to start it sooner rather than later. I went to Stanford undergrad and Stanford Law School, and if I had to do it over again, I might still do those things, but I wish I had asked the type of questions like, why I was doing it, was it just for the status and prestige, or was it because I was really interested in the substance of it.

If you invest in Microsoft or Oracle, or a number of other companies for that matter, you're fundamentally making a bet that there's going to be no innovation. So an investment in Microsoft is a bet that the operating system is going to stay the same, it won't be replaced by Linux, Google Docs, or a mobile platform like iOS or Android.

I'm always very excited about trying to do something on next-generation biotechnology and life sciences because I think if we can cure cancer or dementia, we can really make the future a lot better and I think these things are eminently doable.