I don't have hard numbers about this, but the impression I get is that the amount of eyeballs you get from being on the humor shelf at Barnes & Noble - it is almost insignificant.

Man, Farmville is so huge! Do you realize its the second-biggest browser-based social-networking-centered farming game in the world?

It's tempting to just write a comic called 'Everyone Mail Randall Munroe Twenty Bucks' - maybe it would work, and I could just close down the 'xkcd' store and sit on a beach and draw pictures and make snarky Reddit posts for the rest of my life.

The universe is probably littered with one-planet graves

When designing an interface, imagine that your program is all that stands between the user and hot, sweaty, tangled-bedsheets-fingertips-digging-into-the-back sex.

The thing about the Internet is that you can write something... for a very narrow audience and make a living at it.

You don't use science to show you're right, you use science to become right.