History has got a lot to do with unique circumstances under certain particular cases and grand theories will always find counter cases. I don't think that people whose expertise lies in one thing should try to make grand theories about something (a) where it's very hard to get the evidence to prove that you're right and (b) where it's much too easy to make up stories that seem right.

When the wrong question is being asked, it usually turns out to be because the right question is too difficult. Scientists ask questions they can answer. That is, it is often the case that the operations of a science are not a consequence of the problematic of that science, but that the problematic is induced by the available means.

We do have tendency, now in biology especially to make up stories, to make theoretical biology a kind of game, in fact we have game theory in biology which is meant to use the theory of games to make predictions or explain things.

An ecosystem, you can always intervene and change something in it, but there's no way of knowing what all the downstream effects will be or how it might affect the environment. We have such a miserably poor understanding of how the organism develops from its DNA that I would be surprised if we don't get one rude shock after another.

In my mind the job of a natural scientist is to bend over backwards to say something which can be demonstrated to be true or at least which is not of such a nature that there's no way to demonstrate that it's false.

If I put myself on the side of those who see the world as warming up in a bad way, who see the general march of industrial culture as something undesirable, the one thing I must be beware of doing and which my colleagues on that side don't beware of doing, we must beware of saying we've got to stop changing the environment. There is no 'the' environment which we can change, the world is changing all the time.

With respect to phenomena like mass extinction, somebody might say why worry about it because in a geological perspective mass extinctions aren't so bad, they wipe out some things and then 10 million years down the road we get new and interesting objects.But I tell you mass extinctions are really awful for folks caught in the midst of them.