On an incredibly simplistic level, you can think of depression as occurring when your cortex thinks an abstract thought and manages to convince the rest of the brain that this is as real as a physical stressor.
Robert M. SapolskyTo out-group-members, oxytocin makes you crappier - less cooperative and more preemptively aggressive. It's not the luv hormone. It's the in-group parochialism/xenophobia hormone.
Robert M. SapolskyWe're getting along so well; I trust you so much for this one second that I'm going to let you yank on me.
Robert M. Sapolsky