... no scientific worker has a fixed level of significance at which from year to year, and in all circumstances, he rejects hypotheses; he rather gives his mind to each particular case in the light of his evidence and his ideas.
Ronald FisherThe best causes tend to attract to their support the worst arguments, which seems to be equally true in the intellectual and in the moral sense.
Ronald FisherThe neutral zone of selective advantage in the neighbourhood of zero is thus so narrow that changes in the environment, and in the genetic constitution of species, must cause this zone to be crossed and perhaps recrossed relatively rapidly in the course of evolutionary change, so that many possible gene substitutions may have a fluctuating history of advance and regression before the final balance of selective advantage is determined.
Ronald Fisher