The more highly adapted an organism becomes, the less adaptable it is to any new change.
Ronald FisherNatural selection is a mechanism for generating an exceedingly high degree of improbability.
Ronald Fisher... no scientific worker has a fixed level of significance at which from year to year, and in all circumstances, he rejects hypotheses; he rather gives his mind to each particular case in the light of his evidence and his ideas.
Ronald FisherNo aphorism is more frequently repeated in connection with field trials, than that we must ask Nature few questions, or, ideally, one question, at a time. The writer is convinced that this view is wholly mistaken. Nature, he suggests, will best respond to a logical and carefully thought out questionnaire; indeed, if we ask her a single question, she will often refuse to answer until some other topic has been discussed.
Ronald Fisher