To consult the statistician after an experiment is finished is often merely to ask him to conduct a post mortem examination. He can perhaps say what the experiment died of.
Ronald FisherNo aphorism is more frequently repeated in connection with field trials, than that we must ask Nature few questions, or, ideally, one question, at a time. The writer is convinced that this view is wholly mistaken. Nature, he suggests, will best respond to a logical and carefully thought out questionnaire; indeed, if we ask her a single question, she will often refuse to answer until some other topic has been discussed.
Ronald FisherNo isolated experiment, however significant in itself, can suffice for the experimental demonstration of any natural phenomenon; for the "one chance in a million" will undoubtedly occur, with no less and no more than its appropriate frequency, however surprised we may be that it should occur to us.
Ronald FisherThe statistician cannot excuse himself from the duty of getting his head clear on the principles of scientific inference, but equally no other thinking man can avoid a like obligation.
Ronald FisherIt was Darwin's chief contribution, not only to Biology but to the whole of natural science, to have brought to light a process by which contingencies a priori improbable, are given, in the process of time, an increasing probability, until it is their non-occurrence rather than their occurrence which becomes highly improbable.
Ronald Fisher