Nobody knows what will work until they try it. Some of comics' biggest success stories in recent years have explored subjects that no one was writing about at the time - stories no one had any reason to think would succeed. My advice? Write what you want to read. You'll have more fun doing it - and if all else fails, you'll always have at least one loyal reader.
Scott McCloudI don't think the potential for comics in nonfiction has been exploited nearly as much as it could be.
Scott McCloudI've always been very forward-looking, and it was actually kind of difficult to turn my gaze backwards to look at comics history.
Scott McCloudAs I see it, mainstream comics now speak only to the hardcore few who stayed; conversing in a weird, garbled, visual pig latin only they can understand - rendering the term 'mainstream' a hollow joke - while the true mainstream, the other 99.9% of the populace, find enjoyment elsewhere.
Scott McCloud