As for sticking strictly to presently known science, I will simply point out that we have already experienced at least two major revolutions in science in this century alone.
Stanley SchmidtThere may be something to the suggestion about the pace of technological change intimidating writers, though - it's been awfully hard to keep ahead of real developments.
Stanley SchmidtI think the rising and falling popularity of areas like hard SF and far-future SF is, to a considerable extent, the same as any other fashion.
Stanley SchmidtIt's easy to imagine ways the future can be ugly and depressing. It's harder, but more worthwhile, to imagine plausible ways we can make it better.
Stanley Schmidt