As for sticking strictly to presently known science, I will simply point out that we have already experienced at least two major revolutions in science in this century alone.
Stanley SchmidtWhen something hasn't been around much for a while, and one example of it turns up and catches people's eyes, they go looking for more like it - until they get tired of it again.
Stanley SchmidtThis means I must pay close attention to the writing, but equally so to the scientific background - which sometimes means doing fairly involved calculations.
Stanley Schmidt