Just do something that lights you up, and lights up your customers, and lights up the world and scale to that.

I think that Microsoft will increasingly feel margin pressure from Linux as well as people saying: well actually the applications that really matter to me are not on my PC. And so they're going to be able to extract less of a monopoly rent, so to speak.

Pursue something so important that even if you fail, the world is better off with you having tried.

Data is the next Intel Inside.

Empowerment of individuals is a key part of what makes open source work, since in the end, innovations tend to come from small groups, not from large, structured efforts.

The nice thing about twitter is the architecture of visibility. Email is invisible unless you reach out to someone directly. With Twitter, anyone can follow you and this is one of the big changes that was really introduced by Flickr, was this wonderful idea that you can follow somebody without their permission. Recognizing that relationships are asymmetrical, unlike facebook where we have to acknowledge each other otherwise we can’t see each other.

When you have to prove the value of your ideas by persuading other people to pay for them, it clears out an awful lot of woolly thinking.