In the development of the understanding of complex phenomena, the most powerful tool available to the human intellect is abstraction. Abstraction arises from the recognition of similarities between certain objects, situations, or processes in the real world and the decision to concentrate on these similarities and to ignore, for the time being, their differences.

What is the central core of the subject [computer science]? What is it that distinguishes it from the separate subjects with which it is related? What is the linking thread which gathers these disparate branches into a single discipline. My answer to these questions is simple -it is the art of programming a computer. It is the art of designing efficient and elegant methods of getting a computer to solve problems, theoretical or practical, small or large, simple or complex. It is the art of translating this design into an effective and accurate computer program.

Some problems are better evaded than solved.

You cannot teach beginners top-down programming, because they don't know which end is up.

At first I hoped that such a technically unsound project would collapse but I soon realized it was doomed to success. Almost anything in software can be implemented, sold, and even used given enough determination. There is nothing a mere scientist can say that will stand against the flood of a hundred million dollars. But there is one quality that cannot be purchased in this way - and that is reliability. The price of reliability is the pursuit of the utmost simplicity. It is a price which the very rich find most hard to pay.

There are two ways of constructing a software design: One way is to make it so simple that there are obviously no deficiencies, and the other way is to make it so complicated that there are no obvious deficiencies. The first method is far more difficult.

An ultimate joint challenge for the biological and the computational sciences is the understanding of the mechanisms of the human brain, and its relationship with the human mind.