Writing is a form of self-flagellation.

I think that the best of my generation...have reversed the customary rules of the game and have grown more radical as they have gotten older - a disconcerting but healthy sign. To be sure, there are many youngish old fogies around and even the most illustrious of these, William Buckley, is blessed by a puzzling, recondite but undeniable charm, almost as if beneath that patrician exterior an egalitarian was signaling to get out.

A disruption of the circadian cycle—the metabolic and glandular rhythms that are central to our workaday life—seems to be involved in many, if not most, cases of depression; this is why brutal insomnia so often occurs and is most likely why each day’s pattern of distress exhibits fairly predictable alternating periods of intensity and relief.

The stigma of self-inflicted death is for some people a hateful blot that demands erasure at all costs.

Nonfiction writers are second-class citizens, the Ellis Island of literature. We just can't quite get in. And yes, it pisses me off.

The pain of severe depression is quite unimaginable to those who have not suffered it.

I felt a kind of numbness, an enervation, but more particularly an odd fragility - as if my body had actually become frail, hypersensitive and somehow disjointed and clumsy, lacking normal coordination. And soon I was in the throes of a pervasive hypochondria.