The pain of severe depression is quite unimaginable to those who have not suffered it.
William StyronFurther, Dr. Gold said with a straight face, the pill at optimum dosage could have the side effect of impotence. Until that moment, although I'd had some trouble with his personality, I had not thought him totally lacking in perspicacity; now I was not all sure. Putting myself in Dr. Gold's shoes, I wondered if he seriously thought that this juiceless and ravaged semi-invalid with the shuffle and the ancient wheeze woke up each morning from his Halcion sleep eager for carnal fun.
William StyronA disruption of the circadian cycleโthe metabolic and glandular rhythms that are central to our workaday lifeโseems to be involved in many, if not most, cases of depression; this is why brutal insomnia so often occurs and is most likely why each dayโs pattern of distress exhibits fairly predictable alternating periods of intensity and relief.
William Styron