The finest pieces of software are those where one individual has a complete sense of exactly how the program works. To have that, you have to really love the program and concentrate on keeping it simple, to an incredible degree.

Energy is very primal stuff and there are a lot of leads that are promising, still at a fairly risky stage, but over the next decade some of these breakthrough approaches are going to pay out, and U.S. research and U.S. leadership on this should be part of how it gets solved.

Does the e-mail say it's about 'enlargement' - that might be spam.

OK, I have a nickname. My family calls me 'Trey' because I'm William the third. My dad has the same name, which is always confusing because my dad is well known, and I'm also known.

The world has been very careful to pick very few diseases for eradication, because it is very tough.

It is hard to sell Congress and the American people on foreign aid. Is it harder to do that than it is to sell billionaires on the idea that they should give all their money away.

Take our 20 best people away, and I will tell you that Microsoft will become an unimportant company