Looking at these issues as a businessman, I believe that investing in the world's poorest people is the smartest way that our government spends money.

But the improvements will happen faster and last longer if we can channel market forces, including innovation that's tailored to the needs of the poorest, to complement what governments and nonprofits do. We need a system that draws in innovators and businesses in a far better way than we do today.

Well the Global Fund, because of how well it's worked on not only AIDS, but also malaria and tuberculosis, I'd say it's well accepted. I mean, it's not politically controversial that this is a great humanitarian effort. But budgets are very very tight.

Convert bad news to good news.

You always overestimate what you can get done in a year and underestimate what you can get done in 10 years.

Like a human being, a company has to have an internal communication mechanism, a "nervous system", to coordinate its actions.

America's high schools are obsolete. By obsolete, I don't just mean that they're broken, flawed, or underfunded, though a case could be made for every one of those points. By obsolete, I mean our high schools-even when they're working as designed-cannot teach all our students what they need to know today.