Any artist who really engages with the problems in their medium at that moment and tries to deepen the problems is likely to discover new problems, new possibilities that will excite audiences and continue to excite them.

It seems to me to make as much sense to talk about literature as a large-scale human phenomenon without bringing in evolution as it does to engage in cosmology while you're thinking the universe is still geocentric.

Popper and Nabokov are very different people in some ways - and I'm ready to devote large chunks of my life to both of them. Popper didn't think much of words but thought ideas mattered, and Nabokov didn't think much of ideas, but words mattered, and so on. But both of them had a sense that this is a world of infinite discovery, unending discovery. That quest to discover more in any direction is what I think drives me, and what drives humans, when they're doing the most interesting things.

There's a young Danish guy who has done a lot of work from an evolutionary perspective, Mathias Clasen. Basically, his argument is we've evolved to fear the monstrous, to be very wary of large, unknown, life-threatening forces. In art, we can play with these things in ways that allow us to feel the intensity of the horror, but in "safe mode," if you like, detached from real consequences.

There is behavioral ecology, which looks closely at the difference different ecologies make to behavior and other features of animals and humans. There's evolutionary individual psychology, there's evolutionary social psychology. In Darwin's terms, evolution couldn't exist without variation, and variation is important in behavioral genetics. And so on, and so on. There are so many instances in which evolution actually sharpens the precision, I think, with which one can find out the importance of differences. We're interested in differences as well as commonalities.

If an artwork never gets any attention from anybody, then obviously it's got problems. If it gains attention from a very small elite, then it's presumably doing something. Finnegans Wake gets a lot of attention from certain people who become passionate about it, who are usually very good readers in general. Although - I often talk about costs and benefits - it seems to me the costs of reading Finnegans Wake are not worth the benefits, however many there may be. And it's the same with the more arcane among poets, Zukofsky and so on.

Perhaps the most demanding trick in all of art is to know ways that are going to capture the attention of an audience right now, and yet to also hold an audience hundreds or thousands of years into the future in circumstances you just cannot imagine. You've got to go very deep into human nature to do that.