After you find out all the things that can go wrong, your life becomes less about living and more about waiting.

Someday you will die, and until you know that, you're useless to me.

The only place where you can really surprise or shock the reader, or make someone laugh, is on the lower righthand corner - the very last panel - so as you turn the page, the payoff is in the upper lefthand panel. To pace every story so that there's a setup and a payoff at the page turn was a huge challenge; it's a part of the medium and you really have to learn what can be done in the medium.

Think of spoiled cat food and ulcerated cankers and expired donor organs. That's how beautiful she looks.

What you write should entertain you and serve you first. Don't worry about maintaining anything beyond your own attention. Focus on exorcising your demons in the work. If you can do that, then you'll succeed in the world.

This is why I loved the support groups so much, if people thought you were dying, they gave you their full attention. If this might be the last time they saw you, they really saw you. Everything else about their checkbook balance and radio songs and messy hair went out the window. You had their full attention. People listened instead of just waiting for their turn to speak. And when they spoke, they weren't just telling you a story. When the two of you talked, you were building something, and afterward you were both different than before.

Public taste changes and the aesthetic of a culture changes over time, so the idea isn't to appeal to the aesthetic of the moment and what people will like right now; the idea is to somehow keep yourself in the public memory so that as taste evolves it will eventually come to embrace your thing. So, it's about writing to be remembered rather than writing to be liked.