The only place where you can really surprise or shock the reader, or make someone laugh, is on the lower righthand corner - the very last panel - so as you turn the page, the payoff is in the upper lefthand panel. To pace every story so that there's a setup and a payoff at the page turn was a huge challenge; it's a part of the medium and you really have to learn what can be done in the medium.
Chuck PalahniukThe first time we meet another person an insidious little voice in our heads says, "I might wear eyeglasses or be chunky around the hips or a girl, but at least I'm not Gay or Black or a Jew." Meaning: I may be me- but at least I have the good sense not to be YOU.
Chuck PalahniukWhen nobody will look at you, you can stare a hole in them. Picking out all the little details you'd never stare long enough to get if they'd even just return your gaze, this, this is your revenge.
Chuck Palahniuk