Many people persist in the wrong job, trying year after year to get good at what they're bad at or at what they dislike. Like marrying the wrong person, working in the wrong job is a prescription for a life of toil-and-groan.

From the biological standpoint, people deprived of the human moment in their day-to-day business dealings, actually in all domains of their lives, are losing brain cells - literally - while those who cultivate the human moment are growing them.

It is especially important for managers to know about, neuroplasticity, the greatest discovery in neuroscience in the past 20 years. It refers to the fact that the brain is remarkably plastic. It can grow and change for the better throughout life. In fact, "plastic" denotes the brain's ability to grow and change throughout life.

Young people beginning a career need to realize that there are lots of "buses" in life. More often than not, selecting which one to be on determines success or failure, joy or despair.

In order to do what really matters to you, you have to, first of all, know what really matters to you.

Modern loneliness is an extraverted loneliness, in which the person is surrounded by many people and partakes of much communication but feels unrecognized and more alone and, although connected technically, isolated and even estranged emotionally.

People associate hard work and overload with stress. But, like suffering, stress is complicated. Bad stress is stress that a system can't endure without suffering damage. It is unplanned, uncontrolled, allows no time for rest and recovery, and exceeds the capacity of the system to adjust to it. As the popular phrase suggests, it burns people out and, over time, it can decimate an entire workforce.