I never liked my own species. On why so many of his comics are about animals, in an interview.

I thought some of my earlier cartoons were not exactly great shakes at the time I drew them. Now I see a certain innocence in them. The humor has a kind of purity to it, I guess. And it works better on some level for me now.

The fuel light's on, Frank! We're all going to die! Wait, wait... Oh, my mistake - that's the intercom light.

I think one thing that's important to maintain is a sense of fear, always doubting yourself... a good dose of insecurity helps your work in some ways.

On Career Day in high school, you don't walk around looking for the cartoon guy.

Humans have changed ecosystems more rapidly and extensively than in any comparable period of time in human history, largely to meet rapidly growing demands for food, fresh water, timber, fiber and fuel. This has resulted in a substantial and largely irreversible loss in the diversity of life on Earth.

He has been known by many names: Lucifer, Beelzabub, Belial, the Prince of Lies, Satan, and at a party once an obnoxious drunk kept calling him "Dude."