[Motherhood is] the biggest gamble in the world. It is the glorious life force. It's huge and scary-it's an act of infinite optimism.

Cancer is probably the most unfunny thing in the world, but I'm a comedian, and even cancer couldn't stop me from seeing the humor in what I went through.

... every time I got disappointed I'd remember the Roseannadanna philosophy that says that you shouldn't cry over split milk 'cause if you spill some milk and instead of cleaning it up you just walk over it and start crying, they're gonna put you on lithium.

It's such an act of optimism to get through a day and enjoy it and laugh and do all that without thinking about death. What spirit human beings have!

My life had made me funny, and cancer wasn't going to change that.

While we have the gift of life, it seems to me the only tragedy is to allow part of us to die - whether it is our spirit, our creativity or our glorious uniqueness.

Some stories don't have a clear beginning, middle and end.