Because the character is a fiction, he's a composite of other contributors to the science that brought this enzyme therapy through the process. We had the opportunity to make him up out of those things that helped tell the story. We wanted to create both ally and antagonist for John [in the Extraordinary measures].

Sometimes I try to improve the language, the lines, or the delivery, but I don't ad-lib because I think that makes it really hard for everybody else involved.

I get mad when people call me an action movie star. Indiana Jones is an adventure film, a comic book, a fantasy.

I am not the first man who wanted to make changes in his life at 60 and I won't be the last. It is just that others can do it with anonymity.

I had the idea that the film would be much better served by a Branch Rickey lookalike than a Harrison Ford lookalike. I didn't want the audience to go into the film thinking that they knew me from some previous experience in a movie.

It's the primordial characters [of the Star Wars]. It's the beautiful princess and the callow youth and the smartass that I played and the wise old warrior that Alec Guinness played. And it was a fairy tale. It was a fairy tale.

The environment has become a political, polarizing issue.