I have a reverence for medicine because I hero-worshiped my father [a former doctor], and because I admire doctors, I admire study, empiricism and rational thought. I don't study, empiricize or think rationally myself - but I admire it in others.

As a real person, he wouldn't last a minute, would he? But drama is about imperfection. And we've moved away from the aspirational hero. We got tired of it, it was dull. If I was House's friend, I would hate it. How he so resolutely refuses to be happy or take the kind-hearted road. But we don't always like morally good people, do we?

One of the principal goals in my life has been to avoid embarrassing my children by doing the job I do. I hope I've managed to do that, and I hope that, with the job I'm in now, they are, if not proud, at least unembarrassed by it. I must say, my three are most agreeable children, who do nothing but delight me.

I'm not a religious man... I find I am a fan of science. I believe in science. A humility before the facts. I find that a moving and beautiful thing. And belief in the unknown I find less interesting. I find the known and the knowable interesting enough.

I am very, very aware at all times. I'm watching myself, I'm listening to myself, I'm judging myself, critiquing myself all the time, and I will know when I do something and I will immediately say, "Can I do another one, because I didn't quite get that thing," or that I wanted to do something there and it didn't quite work.

Death and disaster are at our shoulders every second of our lives, trying to get at us. Missing, a lot of the time. A lot of miles on the motorway without a front wheel blow-out. A lot of viruses that slither through our bodies without snagging. A lot of pianos that fall a minute after we've passed. Or a month, it makes no difference. So unless we're going to get down on our knees and give thanks every time disaster misses, it makes no sense to moan when it strikes.

It's a terrible thing, I think, in life to wait until you're ready. I have this feeling now that actually no one is ever ready to do anything. There is almost no such thing as ready. There is only now. And you may as well do it now. Generally speaking, now is as good a time as any.