I have a reverence for medicine because I hero-worshiped my father [a former doctor], and because I admire doctors, I admire study, empiricism and rational thought. I don't study, empiricize or think rationally myself - but I admire it in others.

I get anxious about a lot of things, that's the trouble. I get anxious about everything. I just can't stop thinking about things all the time. And here's the really destructive part - it's always retrospective. I waste time thinking of what I should have said or done.

Newton's Third Law of Conversation, if it existed, would hold that every statement implies an equal and opposite statement. To say that I'd turned the offer down raised the possibility that I might not have done.

Driving a motorcycle is like flying. All your senses are alive. When I ride through Beverly Hills in the early morning, and all the sprinklers have turned off, the scents that wash over me are just heavenly. Being House is like flying, too. You're free of the gravity of what people think.

Believe it or not, perhaps I don't show it much, or well, but I think I like people.

I wouldn't be able to act like Al Pacino or play the piano like Dr. John, But I could probably act better than Dr. John and play the piano better than Al Pacino.

We put this 15-year old girl on the cover of a fashion magazine, and tell everyone she is the epitome of sexual perfection, but we jail anyone who touches her for another three years.