I didn't realize House would be the central character, more the bitter comic relief appearing occasionally. I relish his wounded nature - the lameness, the scarred Byronic hero.

To tell you the truth, the older I get, the less I know. I keep meeting people, both older and younger, who seem to have accrued so much more knowledge or expertise or certainty about who they are and the jobs they do. I just marvel at it.

Perseverance does not equal worthiness. Next time you want to get my attention, wear something fun. Low-riding jeans are hot.

I do actually like Los Angeles. Partly because I was told I wouldn't.

One of the principal goals in my life has been to avoid embarrassing my children by doing the job I do. I hope I've managed to do that, and I hope that, with the job I'm in now, they are, if not proud, at least unembarrassed by it. I must say, my three are most agreeable children, who do nothing but delight me.

I'm not a religious man... I find I am a fan of science. I believe in science. A humility before the facts. I find that a moving and beautiful thing. And belief in the unknown I find less interesting. I find the known and the knowable interesting enough.

I am a coffee fanatic. Once you go to proper coffee, you can't go back. You cannot go back.