I think classical music tuition is, well, was when I was a child, was an abomination. I think in some ways it is one of life's great tragedies for everybody who gives up an instrument.

I have been instrumental in banning bottled water on the set. It hasn't gone that well with the crew... so I replaced it with tequila.

I didn't realize House would be the central character, more the bitter comic relief appearing occasionally. I relish his wounded nature - the lameness, the scarred Byronic hero.

I remember watching Mel Gibson on some show once, and he was being asked about his belief in the afterlife. Gibson said: 'Well, I can't believe this is all there is'. And I thought: 'Wait a minute. You're Mel Gibson. You have millions of dollars. You're a great-looking chap with every conceivable blessing that could be bestowed upon a man. And that's not good enough ?'

Driving a motorcycle is like flying. All your senses are alive. When I ride through Beverly Hills in the early morning, and all the sprinklers have turned off, the scents that wash over me are just heavenly. Being House is like flying, too. You're free of the gravity of what people think.

I get anxious about a lot of things, that's the trouble. I get anxious about everything. I just can't stop thinking about things all the time. And here's the really destructive part - it's always retrospective. I waste time thinking of what I should have said or done.

I think good-looking people seldom make good television. And American television studios almost concede before they start: 'Well, it won't be good, but at least it'll be good-looking. We'll have nice-looking girls in tight shirts with F.B.I. badges and fit-looking guys with lots of hair gel vaulting over things.'