There is almost no such thing as ready. There is only now.

I'm not a religious man... I find I am a fan of science. I believe in science. A humility before the facts. I find that a moving and beautiful thing. And belief in the unknown I find less interesting. I find the known and the knowable interesting enough.

One thing House needs Wilson for is vanity. He needs someone to laugh at his jokes.

I have my moments. Ever since I was a boy, I never was someone who was at ease with happiness. Too often I embrace introspection and self-doubt. I wish I could embrace the good things.

I couldn't imagine what Fox thought they were doing, contemplating such a jagged protagonist for a prime-time drama. I only knew that I wanted the role very much.

Piano was - well, all musical instruments were taught in this very rigid, formal, classical method when I was young.

LA runs on optimism, enthusiasm and flattery. I think you can go a little bit crazy... It's just too damn sunny in every dimension - weatherwise, socially and professionally.