The thing that I've learned about taking risks is that the key question to ask is, "If this goes terribly, what will happen?" Usually, the answer is that the world won't come to a screeching halt. Usually you can go back. Maybe not to the exact same job, but usually to the same type of job.

Whether I'm traveling or at home in Seattle, my days rarely play out as it looks on my Outlook calendar - there's almost always something unexpected that comes up. But when I'm in town, my day usually starts at about 6 a.m., which is brutal for me because I'm really a night owl at heart.

Every day, possibly every hour as an entrepreneur, you do something that you absolutely could have done better with more time, more information, more experience, or more money - all luxuries you can't afford. So you do your best, and you move forward. The key is to see the forward momentum and not beat yourself up about how it could have been better.

When I think about work-life balance, I don't imagine it as a perfect day where I got to spend the exact right amount of time having an impact at work and snuggling with my kids at home. I never achieve that. But over the course of a month, or a quarter, or a year, I try to make time for the people and experiences I value.

I've always had amazing women in my life help me with my kids. First it was my mom, and then a series of nannies and day care providers who were incredibly patient, kind, and loving. There is no blueprint - I think we all feel our way through it and just do the best we can, and it turns out that children are open to love from many different places and are pretty resilient, too.

Women in business, women in employment anywhere face a very different set of challenges than their male counterparts.

The world is more flexible than you might think.