Suffering is always hard to quantify - especially when the pain is caused by as cruel a disease as Alzheimer's. Most illnesses attack the body; Alzheimer's destroys the mind - and in the process, annihilates the very self.

There are popular celebrities, there are unpopular celebrities and then there are the walking dead. You know the walking dead when you see them: they look like Mel Gibson, still striving for drunken charm in an L.A. County mug shot, after getting picked up on a DWI charge that included anti-semitic slurs directed at the police.

Humans have a fraught relationship with beasts. They are our companions and our chattel, our family members and our laborers, our household pets and our household pests. We love them and cage them, admire them and abuse them. And, of course, we cook and eat them.

Every batch of sperm represents an opportunity for genetic typos - called de novo mutations - to be passed on. A 20-year-old man and woman will each pass on about 20 de novo mutations to a baby they conceive. By the time the couple is 40, a woman's total has remained at 20, while a man's has jumped to 65 - and it keeps climbing from there.

There's only one thing harder than living in a home with an adolescent - and that's being an adolescent. The moodiness, the volatility, the wholesale lack of impulse control, all would be close to clinical conditions if they occurred at another point in life. In adolescence, they're just part of the behavioral portfolio.

What people fear most about tragedy is its randomness - a taxi cab jumps the curb and hits a pedestrian, a gun misfires and kills a bystander. Better to have some rational cause and effect between incident and injury. And if cause and effect aren't possible, better that there at least be some reward for all the suffering.

Narcissism is actually a clever guise adopted to mask its exact opposite, which is a deep well of self-loathing, a well of low self-esteem, rather than high self-esteem. This helps explain why narcissists are so sensitive to criticism, why narcissists tend to break into outrage if they're criticized, because their self-esteem is actually much more brittle than it seems, and once they're challenged, that mask falls apart.