Everything previously moving with the grain is now against - you are irritable, angry, frightened, uncontrollable, and enmeshed totally in the blackest caves of the mind. You never knew those caves were there. It will never end, for madness carves its own reality.

Anybody who's had to contend with mental illness - whether it's depression, bipolar illness or severe anxiety, whatever - actually has a fair amount of resilience in the sense that they've had to deal with suffering already, personal suffering.

I had been simply treating water, settling on surviving and avoiding pain rather than being actively involved in seeking out life.

Nothing good comes out of depression.

Without science, there would be no such hope.

I realized that it was not that I didn’t want to go on without him. I did. It was just that I didn’t know why I wanted to go on

I don't think grief of grief in a medical way at all. I think that I and many of my colleagues, are very concerned when grief becomes pathological, that there is no question that grief can trigger depression in vulnerable people and there is no question that depression can make grief worse.