Everything previously moving with the grain is now against - you are irritable, angry, frightened, uncontrollable, and enmeshed totally in the blackest caves of the mind. You never knew those caves were there. It will never end, for madness carves its own reality.

There is a particular kind of pain, elation, loneliness and terror involved in this kind of madness... It will never end, for madness carves its own reality.

But, with time, one has encountered many of the monsters, and one is increasingly less terrified of those still to be met.

The pursuit of knowledge is an intoxicant, a lure that scientists and explorers have known from ancient times; indeed, exhilaration in the pursuit of knowledge is part of what has kept our species so adaptive.

One of the advantages of science is that one's work, ultimately, is either replicated or it is not.

Suicide is not a blot on anyone’s name; it is a tragedy

We all move uneasily within our restraints.