I'm a purist: I start to wrinkle my nose when the Cold War ends.

The act of facing overwhelming odds produces greatness and beauty.

Innovators have to be open. They have to be able to imagine things that others cannot and be willing to challenge their own preconceptions. They also need to be conscientious. An innovator who has brilliant ideas but lacks the discipline and persistence to carry them out is merely a dreamer ... But crucially, innovators need to be disagreeable ... They are people willing to take social risks-to do things that others might disapprove of.

The conventional wisdom is often wrong. Crime didn't keep soaring in the 1990s, money alone doesn't win elections, and - surprise - drinking eight glasses of water a day has never actually been shown to do a thing for your health. Conventional wisdom is often shoddily formed and devilishly difficult to see through, but it can be done.

Occasions when you can change your mind should be cherished, because they mean you're smarter than you were before.

There is this tremendous body of knowledge in the world of academia where extraordinary numbers of incredibly thoughtful people have taken the time to examine on a really profound level the way we live our lives and who we are and where we've been. That brilliant learning sometimes gets trapped in academia and never sees the light of day.

People at CDC [Centers for Disease Control] who cut their teeth on diseases over the last 10 years have started to think of crime as another disease, and using some of these same concepts. It was something that was in the air in that world, but it was time to bust it out and apply it to any number of different social epidemics.