To ensure continuing prosperity in the global economy, nothing is more important than the development and application of knowledge and skills.

I'm a technological optimist in that I do believe that technology will provide solutions that will allow the world in 2050 to support 9 billion people at an acceptable standard of living. But I'm a political pessimist in that I am concerned about whether the science will be appropriately applied.

Devastation could arise insidiously, rather than suddenly, through unsustainable pressure on energy supplies, food, water and other natural resources. Indeed, these pressures are the prime 'threats without enemies' that confront us.

I suspect there could be life and intelligence out there in forms that we can't conceive. And there could, of course, be forms of intelligence beyond human capacity-beyond as much as we are beyond a chimpanzee.

I recall a lecture by John Glenn, the first American to go into orbit. When asked what went through his mind while he was crouched in the rocket nose-cone, awaiting blast-off, he replied, "I was thinking that the rocket has 20,000 components, and each was made by the lowest bidder."

If we ever establish contact with intelligent aliens living on a planet around a distant star ... They would be made of similar atoms to us. They could trace their origins back to the big bang 13.7 billion years ago, and they would share with us the universe's future. However, the surest common culture would be mathematics.

I think all countries need to aim to cut the CO2 emissions per person, taking account of externalities like imports and exports.