'The Simpsons' was about children and married parents; 'Futurama' is about people in between; they're growing up and haven't settled down. Every other cartoon show seemed to be, you know, dumb dad, bratty kids.
The entire world of grown-ups is corrupt and stupid.
I'd be vegetarian if bacon grew on trees
Are we alone in an uncaring universe, or is God some kind of wiseguy?
Being a good embalmer is a thankless job.
The thing about a cartoon is, you can do whatever you want. The tightrope that we are walking on 'The Simpsons' and 'Futurama' is "How do you continue to surprise the audience, but make them good surprises?" Not every surprise is good, but you want to continue jolting people.