The world's biggest problems are the world's biggest business opportunities.

You have to ask yourself the question, do you have the smartest people in the world working for your company? And if you do, you're lucky. But if you don't, put up the incentive. And have someone who is absolutely brilliant who's a 22-year old in India who says what about this way? And who revolutionizes the way you do business.

What opened up the American West was the fact that you owned the real estate. You owned the gold mines, the oil wells. The creation of these, back then, million dollar industries drove the railroads and eventually the airlines to provide this kind of transportation.

The question companies have to ask, or governments have to ask is, where do we allow crazy ideas to bubble up? Because if there is a failure, what happens? Someone gets blame. There's a lawsuit, there's a congressional investigation. And so, those things shut down the creative engine.

By 2020 the U.S. will be short 91,000 doctors. There's no way we can educate enough doctors to make up that shortfall, and other countries are far worse off.

Imagine a world of nine billion people with clean water, nutritious food, affordable housing, personalized education, top-tier medical care, and nonpolluting, ubiquitous energy. Building this better world is humanity's grandest challenge.

The meek shall inherit the earth. The rest of us are going to the stars.