A startup is the largest endeavor over which you can have definite mastery. You can have agency not just over your own life, but over a small and important part of the world. It begins by rejecting the unjust tyranny of Chance. You are not a lottery ticket.

Forget startup companies. The next frontier is startup countries.

A true bubble is when something is overvalued and intensely believed.

Had the people who started Facebook decided to stay at Harvard, they would not have been able to build the company, and by the time they graduated in 2006, that window probably would have come and gone.

The lowest-hanging fruit in preventative medicine is just to really focus on nutrition.

You'll attract the employees you need if you can explain why your mission is compelling: not why it's important in general, but why you're doing something important that no one else is going to get done.

Never invest in a tech CEO that wears a suit.