We don't beat the reaper by living longer, but by living well, and living fully - for the reaper will come for all of us. The question is: what do we do between the time we're born and the time he shows up.

A lot of people want a shortcut. I find the best shortcut is the long way, which is basically two words: work hard.

The fact that fashion goes out of fashion and then comes back into fashion based solely on what a few people somewhere think they can sell, well to me, that’s insanity.

There's a lot of talk these days about giving children self-esteem. It's not something you can give; it's something they have to build. Coach Graham worked in a no-coddling zone. Self-esteem? He knew there was really only one way to teach kids how to develop it: You give them something they can't do, they work hard until they find they can do it, and you just keep repeating the process.

It's a thrill to fulfill your own childhood dreams, but as you get older, you may find that enabling the dreams of others is even more fun.

I was hugely impressed... was the ultimate example of a man who knew what he didn't know, was perfectly willing to admit it, and didn't want to leave until he understood. That's heroic to me. I wish every grad student had that attitude.

I understand the arguments about how the billions of dollars spent to put men on the moon could have been used to fight poverty and hunger on Earth. But, look, I'm a scientist who sees inspiration as the ultimate tool for doing good. When you use money to fight poverty, it can be of great value, but too often, you're working at the margins. When you're putting people on the moon, you're inspiring all of us to achieve the maximum of human potential, which is how our greatest problems will eventually be solved. Give yourself permission to dream.