Experience matters for some roles and not others.
Most of the best hires that I've made in my entire life have never done that thing before.
You're either not hiring at all or it's probably your single biggest block of time.
You should be giving out a lot of equity to your employees.
Most great companies in tech have been built by personal referrals for the first...at least 100 employees and often many more.
Facebook has this famous poster that says move fast and break things. But at the same time they manage to be obsessed with quality.