From the Buddhist point of view, it is true that emptiness is a characteristic of all of life - if we look carefully at any experience we will find transparency, insubstantiality, with no solid, unchanging core to our experience. But that does not mean that nothing matters.
Sharon SalzbergThere's a famous quotation from the time the Buddha learned of the deaths of two of his greatest disciples: "It's as if the sun and the moon have left the sky." From that quotation, I would guess that while the Buddha loved all beings everywhere, with no exclusion, he also had relationships that were special to him, and he felt their loss.
Sharon Salzberg