Everyone knows that marriage is the biggest personal decision you make, but it's the biggest career decision you can make.

For any of us in this room today, let's start out by admitting we're lucky. We don't live in the world our mothers lived in, our grandmothers lived in, where career choices for women were so limited.

After my husband, Dave, died, I called my friend Adam, a psychologist who studies how people find meaning in our lives, and I asked him what, if anything, I could do to help myself and my kids get through this. We started talking about resilience, then reading about it, then talking to other people who had gotten through grief and other huge challenges. In time, those conversations and that research helped me heal.

You know, there has never been a 24-hour period in five years when I have not responded to e-mail at Facebook. I am not saying it's easy. I work long hours.

Social media has created a historical shift from the historically powerful to the historically powerless. Now everyone has a voice.

I have never met a woman, or man, who stated emphatically, "Yes, I have it all.'" Because no matter what any of us has—and how grateful we are for what we have—no one has it all.

People assume Wall Street is a certain culture and tech is a certain culture. But if you look at the (gender) numbers at the top of (those) industries, they don't vary very much. I think in finance, women hold 19 percent of the top jobs, and women are 21 percent of the leaders in nonprofits.