But the upside of painful knowledge is so much greater than the downside of blissful ignorance.

What about the rat race in the first place? Is it worthwhile? Or are you just buying into someone else's definition of success? Only you can decide that, and you'll have to decide it over and over and over. But if you think it's a rat race, before you drop out, take a deep breath. Maybe you picked the wrong job. Try again. And then try again.

You know, there has never been a 24-hour period in five years when I have not responded to e-mail at Facebook. I am not saying it's easy. I work long hours.

Every woman I know, particularly the senior ones, has been called too aggressive at work. We know in gender blind studies that men are more aggressive in their offices than women. We know that. Yet we're busy telling all the women that they're too aggressive. That's the issue.

When you want to change things, you won't please everyone.

The traditional metaphor for careers is a ladder, but I no longer think that metaphor holds. It just doesn’t make sense in a less hierarchical world... Build your skills, not your resume. Evaluate what you can do, not the title they’re going to give you. Do real work. Take a sales quota, a line role, an ops job. Don’t plan too much, and don’t expect a direct climb. If I had mapped out my career when I was sitting where you are, I would have missed my career.

Endless data show that diverse teams make better decisions. We are building products that people with very diverse backgrounds use, and I think we all want our company makeup to reflect the makeup of the people who use our products. That's not true of any industry really, and we have a long way to go.