As for sticking strictly to presently known science, I will simply point out that we have already experienced at least two major revolutions in science in this century alone.
Stanley SchmidtWhen something hasn't been around much for a while, and one example of it turns up and catches people's eyes, they go looking for more like it - until they get tired of it again.
Stanley SchmidtThere are a significant number of people who appreciate what we do, and most of them gravitate to Analog because this is where they can find it. The other magazines tend to share their audiences, which may result in each of them having a smaller market share.
Stanley SchmidtWhat SF can do better than anything else is show us the range of our possible futures, and what we can do to realize the good ones and avoid the nasty ones.
Stanley Schmidt