I think Memento movie was hard because people didn't get it, they just didn't understand it. Not from the stage when we read the script and liked it. It's sort of a famous story now how we finished the movie and showed it to distributors and nobody wanted it. So it wasn't just they didn't get the script, they really didn't even understand the movie when it was done. But I think that was a particularly hard one. I don't think it was harder because we were girls, but I do think obviously there are particular challenges to working in a male-dominated industry.

I don't think actually that kind of ego check or "I could do better" mentality probably serves better in Hollywood, because it's definitely not a meritocracy. You can look at any number of careers and sort of see that they don't really make sense if it was only based on your movies working either creatively or financially. There are people that move ahead without that, and there are people that don't move ahead even if they did have that.

There's a thing about Hollywood where there are at least a couple of guys that behind closed doors and in small circles we think of as having a magical P.T. Barnum quality. Which is to say, they may not be the most talented, and they may not be the smartest, but their movies made money or won awards, so they move ahead.

Even when you're casting, casting is always one of the weirdest subjective areas. You can get a group of people who would decide and say, "This person is a great actor and this person is less than a great actor," but there will always be somebody else who likes that person better than you based on their experience in their other films.

Somebody asked me, "When was the last time it was harder for you as a woman"? And I was like, "What time is it? Do you mean today?" I hate to say that, because it sounds so depressing, but it absolutely happens in many many ways all the time, large and small ways. But it's not like it creates new pain for me on a daily basis, it's just a pain that I accepted long ago. It's definitely harder.

I remember somebody had said to me "What're you doing with a movie like Boiler Room? It's all men and you're a woman. You should be making romantic comedies," or something like that. Boiler Room, for me, was a morality tale. I remember this interview where they said to me "Yeah, but all the characters are men," and I was like, "But I'm a girl, I like men!" It's not like there's nothing interesting to me just because a lot of characters in that movie happen to be male. Just because I'm a girl doesn't mean I only wanna make Must Love Dogs over and over again.

Just watching Chris Nolan direct was amazing. He is one of the most lovely people, which as you know doesn't always go hand-in-hand with great directors. But with Christopher Nolan, and there's only a few I think like him in Hollywood, that's absolutely true.