Agnosticism is not properly described as a "negative" creed, nor indeed as a creed of any kind, except in so far as it expresses absolute faith in the validity of a principle which is as much ethical as intellectual.
Thomas HuxleyFrom the dawn of exact knowledge to the present day, observation, experiment, and speculation have gone hand in hand; and, whenever science has halted or strayed from the right path, it has been, either because its votaries have been content with mere unverified or unverifiable speculation (and this is the commonest case, because observation and experiment are hard work, while speculation is amusing); or it has been, because the accumulation of details of observation has for a time excluded speculation.
Thomas HuxleyEducation is the instruction of the intellect in the laws of Nature, under which name I include not merely things and their forces, but people and their ways; and the fashioning of the affections and of the will into an earnest and loving desire to move in harmony with those laws.
Thomas HuxleyAs for your doctrines I am prepared to go to the Stake if requisite ... I trust you will not allow yourself to be in any way disgusted or annoyed by the considerable abuse & misrepresentation which unless I greatly mistake is in store for you... And as to the curs which will bark and yelp - you must recollect that some of your friends at any rate are endowed with an amount of combativeness which (though you have often & justly rebuked it) may stand you in good stead - I am sharpening up my claws and beak in readiness.
Thomas Huxley