I would not trade any of these features for anybody else’s. I wouldn’t trade the small thin-lipped mouth that makes me resemble my nephew. I wouldn’t even trade the acne scar on my right cheek, because that recurring zit spent more time with me in college than any boy ever did.

Mary Tyler Moore was a working woman whose story lines were not always about dating and men. They were about work friendships and relationships, which is what I feel my adult life has mostly been about.

For my first show at 'SNL', I wrote a Bill Clinton sketch, and during our read-through, it wasn't getting any laughs. This weight of embarrassment came over me, and I felt like I was sweating from my spine out. But I realized, 'Okay, that happened, and I did not die.' You've got to experience failure to understand that you can survive it.

Acting is really about showing up that day and telling the writers what you feel like saying.

[Television] is a great medium for writers, because there's just no time for a studio to interfere very long. You write it, you shoot it; it's on TV.

Whenever you see me, I'm on antique quaaludes.

Gravity”: “It’s the story of how George Clooney would rather float away into space and die then spend one more minute with a woman his own age.