But at the end of the day, the circumstances of your life what you look like, where you come from, how much money you have, what you've got going on at home that's no excuse ... Where you are right now doesn't have to determine where you'll end up. No one's written your destiny for you. Here in America, you write your own destiny. You make your own future.

There have been periods where the folks who were already here suddenly say, 'Well, I don't want those folks,' even though the only people who have the right to say that are some Native Americans.

We rise and fall as one people, one nation.

Usually, I'm pretty good about sorting through the options and then making decisions that I'm confident are the best decisions in that moment, given the information we have. But there are times where I think I wish I could have imagined a different level of insight.

If you look at countries like South Africa, where you had a black majority, there have been efforts to tax and help that black majority, but it hasn't come in the form of a formal reparations program.

It continues to be my strong belief that the way we are going to make sure that everybody feels a part of this global economy is not by shutting ourselves off from each other, even if we could, but rather by working together more effectively than we have in the past.

If we want to make the best products, we also have to invest in the best ideas... Every dollar we invested to map the human genome returned $140 to our economy... Today, our scientists are mapping the human brain to unlock the answers to Alzheimer's... Now is not the time to gut these job-creating investments in science and innovation. Now is the time to reach a level of research and development not seen since the height of the Space Race.