The brain seems a thoroughfare for nerve-action passing its way to the motor animal. It has been remarked that Life's aim is an act not a thought. To-day the dictum must be modified to admit that, often, to refrain from an act is no less an act than to commit one, because inhibition is coequally with excitation a nervous activity.
Charles Scott SherringtonFurther study of central nervous action, however, finds central inhibition too extensive and ubiquitous to make it likely that it is confined solely to the taxis of antagonistic muscles.
Charles Scott SherringtonIf we denote excitation as an end-effect by the sign plus (+), and inhibition as end-effect by the sign minus (-), such a reflex as the scratch-reflex can be termed a reflex of double-sign, for it develops excitatory end-effect and then inhibitory end-effect even during the duration of the exciting stimulus.
Charles Scott SherringtonSwiftly the head mass becomes an enchanted loom where millions of flashing shuttles weave a dissolving pattern, always a meaningful pattern though never an abiding one...
Charles Scott Sherrington