The list of fun and easily fixed brain diseases is very short.

You're always on duty because you're in a constant state of observation. That's one of the challenges of being a comedian. I think one of the other challenges is that, whether we like it or not, it's a profession that requires failure. It doesn't just encourage failure. It requires it because it's all trial and error. You need to know what doesn't work to know what works.

Our fear leads us to say no all the time.

I struggled with that notion early in my career. 'I know this is funny but nobody is laughing.' This thought occurred for years.

Elia Kazan. He wrote my favorite book about filmmaking, 'Elia Kazan: On Directing.' There is a thing in the book that I do every time, it's part of my production structure. He said when you're hiring an actor, ask them what draws them to the project, and don't lead them to the answer.

When I made 'Sleepwalk with Me,' many people asked me if was a novelty thing, a one-off. But this is the goal, I'm just hitting it 12 years after I thought I would.

Eugene Mirman is the Andy Warhol of comedy. People look to him for what's next in comedy, and he emails these people back promptly. The Will to Whatevs put me in a great mood because I was laughing out loud. Alone. That's hard to do.