Even if you know a character really well, there's no formula for what jokes will work and what won't.
Seth MacFarlanereligion notoriously claims that they invented morality, they didn't. Morality exists in animals, ya know.
Seth MacFarlaneThe average person has eight different jobs over the course of their lifetime. You get a little antsy doing the same thing.
Seth MacFarlaneI'm wide open to getting married, but actors are not easy people to date. You end up sharing that person with this other mistress that is their career. I very much like the traditional courtship method of making a date. That's what they do in normal places, but Hollywood's not normal.
Seth MacFarlane