When I was a little kid, I used to say, "I would rather host the Oscars than win an Oscar." To me, that seemed like the more appealing, fun gig.

It was amazing how much their [Seth Rogen, Evan Goldberg, Shauna Robertson] process seemed familiar to me, translating that into the work that I had done and giving actors a lot of freedom and doing a lot of improvisation and a total respect and collaboration with all the department heads and all the crews, and just really making it an enjoyable industry rather than just clocking in and doing a job which a lot of movies are.

Most comedy comes out of misery.

I think around that time I met David [Gordon Green] or, well, we all met at Superbad and Judd [Apatow] said, 'I'm thinking about having him direct [ Knocked Up].' Sounded like a good idea.

You can actually improvise a lot as a voice actor. It's not that entirely different than shooting a live action movie; the characters mouths are quite easy to manipulate once all the information is built into the computer. So you can improvise a lot and it doesn't matter really how far along they are in the process they can really just make the character say something different.

There is no such thing as a villain. It's the others who are wrong. In as much, all villains are the same.

I always thought realistic was a better way to explain things that were "dramedies" because life is like that. It's funny, it's dramatic and to me that's how I see it.