Keep your eye on the prize and focus on your mission. Remember what you’re trying to do, what your value is, why it’s important, and at the same time, change course and direction. If the market’s telling you different things how are you going to adjust to that?

If you're doing something new you've got to have a vision. You've got to have a perspective. You've got to have some north star you're aiming for, and you just believe somehow you'll get there, which kind of gets to the passion point.

So we believed that strategic alliances and partnerships were critical, and we did that for five years.

It's stunning to me what kind of an impact even one person can have

If you really got the right people, and you've got them working together as a team, whether it's in business, whether it's in science, whether it's in politics, you can make a big difference.

And I'd say one of the great lessons I've learned over the past couple of decades, from a management perspective, is that really when you come down to it, it really is all about people and all about leadership.

One of the biggest challenges we had in the first decade was not that many people had personal computers. There weren't that many people to sell to, and it was hard to identify them.