Time is the worst place, so to speak, to get lost in, as Arthur Dent could testify, having been lost in both time and space a good deal. At least being lost in space kept you busy.

I was created to fulfill a function and I failed in it. I negated my own existence.

Well, I mean, yes idealism, yes the dignity of pure research, yes the pursuit of truth in all its forms, but there comes a point I'm afraid where you begin to suspect that the entire multidimensional infinity of the Universe is almost certainly being run by a bunch of maniacs. And if it comes to a choice between spending yet another ten million years finding that out, and on the other hand just taking the money and running, then I for one could do with the exercise.

But for a moment Dirk had a sense of inifinite loss and sadness that somewhere among the frenzy of information noise that daily rattled the lives of men he thought he might have heard a few notes that denoted the movements of gods.

Deep in the fundamental heart of mind and Universe there is a reason.

Trillian had come to suspect that the main reason [Zaphood] had had such a wild and successful life was that he never really understood the significance of anything he did.

All opinions are not equal. Some are a very great deal more robust, sophisticated and well supported in logic and argument than others.