The great thing about fact-based decisions is that they overrule the hierarchy.

We were hoping to build a small profitable company; and of course, what we've done is build a large, unprofitable company.

Good ideas will always get funded, so that's not going to be a problem. But you will see that it will be harder and harder for bad ideas to get funded.

You don't choose your passions; your passions choose you.

The framework I found which made the decision incredibly easy was what I called — which only a nerd would call — a “regret minimization framework.” So, I wanted to project myself forward to age 80 and say, “Okay, now I’m looking back on my life. I want to have minimized the number of regrets I have.”

E-mail has some magical ability to turn off the politeness gene in a human being.

If you are going to do large-scale invention, you have to be willing to do three things: You must be willing to fail; you have to be willing to think long term; and you have to be willing to be misunderstood for long periods of time.